Is glutathione safe for skin?

By the GlutaNex team · Updated 11 October 2026 · 4 sources cited

Short answer: glutathione creams and face washes are generally safe for most adults when used as directed. Glutathione injections for skin lightening are not considered safe and should be avoided.

Glutathione creams

In the 10-week study of a 2% glutathione lotion (Watanabe et al., 2014), only one of 30 women had mild redness, which cleared within two days without stopping. A 2025 systematic review (Khanna et al., J Clin Aesthet Dermatol 2025) found topical glutathione generally well tolerated, but noted that safety data are still limited. As with any skincare, irritation is possible, especially in products that also contain retinol or acids.

Glutathione tablets

Short studies of oral glutathione reported mostly mild effects, but they were small and short. Tablets are supplements, so talk to a doctor first, especially if you take other medicines, have a medical condition or are pregnant.

Glutathione injections

The US FDA warning, 2015 warned that injectable skin-lightening products may be unsafe or ineffective and may contain unknown ingredients. The Indian Journal of Dermatology review (Sonthalia, Daulatabad & Sarkar, IJDVL 2016) noted that no clinical trial supports IV glutathione for skin lightening, listed reported concerns, and advised dermatologists against using it for this purpose. Fake or contaminated injections sold online or in salons add further risk.

Who should be careful

• Pregnant or breastfeeding women (and avoid retinol products unless a doctor approves).
• People with eczema, rosacea, or very sensitive or broken skin.
• Anyone using prescription creams for acne or pigmentation.

How to patch test

1. Apply a little behind the ear or on the inner arm.
2. Wait 24 hours.
3. No redness or itching? Start on the face, slowly.

Stop and see a doctor if

• Redness, burning or itching does not settle within a few days.
• You develop swelling, a rash or blisters.
• Your skin becomes patchy, much lighter in areas, or thin and sensitive.

Frequently asked questions

General information about cosmetic skincare, not medical advice. Results vary from person to person. See a dermatologist for persistent or changing pigmentation.